When creating different desktops in Windows 10 (WIN+tab) it seems you can only have one taskbar across all desktops.
Ideally I want to have a personal desktop and a work one which have different items pinned to taskbar.
Is it possible to configure the virtual desktops in Windows 10 to have different taskbars?
It is the same task bar, yes. And you cannot have radically different task bars.
It may be possible, for apps with multiple instance capabilities to have one icon on a desktop for one instance and another icon on a different desktop for the other instance.
Practically speaking, the answer to your question is no, you cannot have different task bars on different desktops, at least not natively within Windows 10.